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St. Joseph's Health Care London
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The Mobility Brief
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The Gray Centre for Mobility and Activity
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This week in The Mobility Brief, work from Manuel Montero-Odasso examines the global state of fall prevention for older adults, from policy integration to minimal action across 18 countries. We also look at research identifying which combinations of modifiable risk factors have the most detrimental effect on cognition over three years. A separate trial on older adults with mild cognitive impairment reveals how combining aerobic-resistance exercise with cognitive training can affect gait performance and the risk of falls, and whether vitamin D supplementation offers any additional benefits.
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How are countries putting new global guidelines for preventing falls into practice?
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There is no global overview of how different countries are using the 2022 world guidelines for preventing falls in older adults. To address this, researchers contacted experts from 18 countries who took part in the guidelines' development to inquire about the implementation status in their nations.
※ Go to summary or article → Seppala, Lotta J., et al. "The World Falls Guidelines: How Is Implementation Progressing Globally?" Age and Ageing, vol. 54, no. 8, 1 Aug. 2025, article afaf214. https://doi.org/10.1093/ageing/afaf214. ※ Manuel Montero-Odasso →
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Which combination of common health risks most affects thinking skills?
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The optimal combinations of modifiable risk factors to target in dementia prevention efforts are currently unclear. Researchers analyzed data from over 30,000 adults to identify the most frequent combinations of 12 risk factors and examine their association with cognitive changes over three years.
※ Go to summary or article → Son, Surim, Mark Speechley, Guangyong Zou, and Manuel Montero-Odasso. "Identifying the optimal combinations of modifiable dementia risk factors to target in multidomain intervention – Three-year longitudinal findings from the Canadian longitudinal study on aging." The Journal of Prevention of Alzheimer's Disease, Aug. 2025, article 100321. https://doi.org/10.1016/j.tjpad.2025.100321. ※ Manuel Montero-Odasso →
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Does combining exercise for the body and brain help prevent falls in older adults with mild cognitive impairment?
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Older adults with mild cognitive impairment have a higher risk of gait impairments and falls, but how multimodal interventions affect their mobility is unclear. This study evaluated the effects of a 20-week program combining aerobic-resistance exercise, cognitive training, and vitamin D supplementation on gait and falls in participants aged 65 to 84.
※ Go to summary or article → Pieruccini-Faria, Frederico, et al. "Synergistic Effects of Exercise, Cognitive Training and Vitamin D on Gait Performance and Falls in Mild Cognitive Impairment—Secondary Outcomes from the SYNERGIC Trial." Age and Ageing, vol. 54, no. 9, Aug. 2025, article afaf242. https://doi.org/10.1093/ageing/afaf242. ※ Manuel Montero-Odasso →
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The Gray Centre for Mobility and Activity
St. Joseph's Health Care London
550 Wellington Rd London, ON, N6C 0A7, CA
jeff.weiler@sjhc.london.on.ca
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