This month's issue examines the connections between the brain, movement, and recovery across different populations and contexts. Contributions from Robert Teasell, Jamie Fleet, Ricardo Viana, Michael Payne, and Sue Peters characterize global trends in randomized controlled trials for lower extremity stroke rehabilitation, noting a recent acceleration in studies from low-to-middle-income countries. In a related case series, Sue Peters, Robert Teasell, Ricardo Viana, Jaspreet Bhangu, and Jamie Fleet use neuroimaging to document prefrontal cortex activation in females recovering from stroke. The interplay of walking and cognition is also a focus, as Manuel Montero-Odasso outlines future research paths for understanding dual-task gait in people with Mild Cognitive Impairment. The issue also includes teaching images from Eldon Loh on a patient-specific knee procedure.

The relationship between brain structure, cognition, and a person's ability to perform two tasks at once is not fully understood, particularly in early neurodegeneration. To study this, researchers plan to use a variety of brain imaging methods, new task designs with voice and eye-tracking, and analyses that account for different subtypes within Mild Cognitive Impairment (MCI) populations.

Potential disparities exist in research on lower extremity motor recovery after a stroke depending on a country's economic resources. To address this, researchers conducted a systematic search of scientific databases to characterize randomized controlled trials of rehabilitation interventions from high-income and low-to-middle-income countries.

It is unclear why females experience worse functional outcomes, such as poorer balance and slower walking, than males after a stroke. To investigate this, researchers used brain imaging to collect prefrontal cortex activation data from four females as they performed standing and ankle tasks upon admission to and discharge from a stroke rehabilitation unit.

Customizing a medical procedure known as knee radiofrequency ablation for individual patients is a clinical objective. Researchers used contrast spread analysis and knowledge of 3D anatomy to generate teaching images related to this procedure.